Download E-books Drug Metabolism and Transport: Molecular Methods and Mechanisms (Methods in Pharmacology and Toxicology) PDF

A compendium of confirmed experimental ways and methods for learning the bioactivation, cleansing, tissue distribution, and removing of xenobiotics within the metabolism and/or delivery of assorted chemical substances. The authors tackle a number of of the main drug metabolizing platforms, together with the cytochrome P450 family members, flavin-containing monooxygenases, glutathione, S-transferase, glucuronidation, N-acetylation, and sulfotransferases. extra chapters current novel techniques to the learn of: signaling pathways within the rules of drug metabolism enzymes, how the modulation of thiols and different low molecular-weight cofactors can regulate drug metabolism, and the way modulation of drug metabolism pathways can impression antiviral treatment.

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